Neural adaptation or sensory adaptation is a gradual decrease over time in the responsiveness of the
sensory system
The sensory nervous system is a part of the nervous system responsible for processing sensory information. A sensory system consists of sensory neurons (including the sensory receptor cells), neural pathways, and parts of the brain involved i ...
to a constant
stimulus
A stimulus is something that causes a physiological response. It may refer to:
*Stimulation
**Stimulus (physiology), something external that influences an activity
**Stimulus (psychology), a concept in behaviorism and perception
*Stimulus (economi ...
. It is usually
experienced
Experience refers to conscious events in general, more specifically to perceptions, or to the practical knowledge and familiarity that is produced by these conscious processes. Understood as a conscious event in the widest sense, experience involv ...
as a change in the stimulus. For example, if a hand is rested on a table, the table's surface is immediately felt against the skin. Subsequently, however, the sensation of the table surface against the skin gradually diminishes until it is virtually unnoticeable. The sensory neurons that initially respond are no longer stimulated to respond; this is an example of neural adaptation.
All sensory and neural systems have a form of adaptation to constantly detect changes in the environment. Neural receptor cells that process and receive stimulation go through constant changes for mammals and other living organisms to sense vital changes in their environment. Some key players in several neural systems include Ca
2+ions (see
Calcium in biology
Calcium ions (Ca2+) contribute to the physiology and biochemistry of organisms' cell (biology), cells. They play an important role in signal transduction pathways, where they act as a second messenger, in neurotransmitter release from neurons, in ...
) that send negative feedback in second messenger pathways that allow the neural receptor cells to close or open channels in response to the changes of ion flow. There are also mechanoreception systems that use calcium inflow to physically affect certain proteins and move them to close or open channels.
Functionally, it is highly possible that adaptation may enhance the limited response range of neurons to encode sensory signals with much larger dynamic ranges by shifting the range of stimulus amplitudes.
Also, in neural adaptation there is a sense of returning to baseline from a stimulated response.
Recent work suggests that these baseline states are actually determined by long-term adaptation to the environment.
Varying rates or speed of adaptation is an important indicator for tracking different rates of change in the environment or the organism itself.
Current research shows that although adaptation occurs at multiple stages of each sensory pathway, it is often stronger and more stimulus specific at "cortical" level rather than "subcortical stages".
In short, neural adaptation is thought to happen at a more central level at the
cortex
Cortex or cortical may refer to:
Biology
* Cortex (anatomy), the outermost layer of an organ
** Cerebral cortex, the outer layer of the vertebrate cerebrum, part of which is the ''forebrain''
*** Motor cortex, the regions of the cerebral cortex i ...
.
Fast and slow adaptation
There is fast adaptation and slow adaptation. Fast adaptation occurs immediately after a stimulus is presented i.e., within hundreds of milliseconds. Slow adaptive processes can take minutes, hours or even days. The two classes of neural adaptation may rely on very different physiological mechanisms.
The time scale over which adaptation builds up and recovers depends on the time course of stimulation.
Brief stimulation produces adaptation which occurs and recovers while more prolonged stimulation can produce slower and more lasting forms of adaptation.
Also, repeated sensory stimulation appears to temporarily decrease the gain of thalamocortical synaptic transmission. Adaptation of cortical responses was stronger and recovered more slowly.
History
In the late 1800s,
Hermann Helmholtz
Hermann Ludwig Ferdinand von Helmholtz (31 August 1821 – 8 September 1894) was a German physicist and physician who made significant contributions in several scientific fields, particularly hydrodynamic stability. The Helmholtz Association, ...
, a German physician and physicist, extensively researched conscious sensations and different types of perception. He defined sensations as the "raw elements" of conscious experience that required no learning, and perceptions as the meaningful interpretations derived from the senses. He studied the physical properties of the eye and vision, as well as acoustic sensation. In one of his classic experiments regarding how space perception could be altered by experience, participants wore glasses that distorted the
visual field
The visual field is the "spatial array of visual sensations available to observation in introspectionist psychological experiments". Or simply, visual field can be defined as the entire area that can be seen when an eye is fixed straight at a point ...
by several degrees to the right. Participants were asked to look at an object, close their eyes, and try to reach out and touch it. At first, the subjects reached for the object too far to the left, but after a few trials were able to correct themselves.
![Blinking in Upside Down Goggles](https://upload.wikimedia.org/wikipedia/commons/2/23/Blinking_in_Upside_Down_Goggles.gif)
Helmholtz theorized that perceptual adaptation might result from a process he referred to as
unconscious inference Unconscious inference (German: unbewusster Schluss), also referred to as unconscious conclusion, is a term of perceptual psychology coined in 1867 by the German physicist and polymath Hermann von Helmholtz to describe an involuntary, pre-rational an ...
, where the mind unconsciously adopts certain rules in order to make sense of what is perceived of the world. An example of this phenomenon is when a ball appears to be getting smaller and smaller, the mind will then infer that the ball is moving away from them.
In the 1890s, psychologist
George M. Stratton
George Malcolm Stratton (September 26, 1865 – October 8, 1957) was an American psychologist who pioneered the study of perception in vision by wearing special glasses which inverted images up and down and left and right. He studied under ...
conducted experiments in which he tested the theory of perceptual adaptation. In one experiment, he wore a
reversing glasses for 21½ hours over three days. After removing the glasses, "normal vision was restored instantaneously and without any disturbance in the natural appearance or position of objects."
On a later experiment, Stratton wore the glasses for eight whole days. By day four, the images seen through the instrument were still upside down. However, on day five, images appeared upright until he concentrated on them; then they became inverted again. By having to concentrate on his vision to turn it upside down again, especially when he knew images were hitting his
retina
The retina (from la, rete "net") is the innermost, light-sensitive layer of tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which then ...
s in the opposite orientation as normal, Stratton deduced his brain had adapted to the changes in vision.
Stratton also conducted experiments where he wore glasses that altered his
visual field
The visual field is the "spatial array of visual sensations available to observation in introspectionist psychological experiments". Or simply, visual field can be defined as the entire area that can be seen when an eye is fixed straight at a point ...
by 45°. His brain was able to adapt to the change and perceive the world as normal. Also, the field can be altered making the subject see the world upside down. But, as the brain adjusts to the change, the world appears "normal."
In some extreme experiments, psychologists have tested to see if a pilot can fly a plane with altered vision. All of the pilots that were fitted with the goggles that altered their vision were able to safely navigate the aircraft with ease.
Visual
Adaptation is considered to be the cause of perceptual phenomena like
afterimage
AfterImage is a Filipino rock band formed in 1986, best known for their songs "Habang May Buhay", "Next in Line", and "Mangarap Ka". They disbanded in 1997 and became active again in 2008 after they reunited and released their fourth studio album ...
s and the motion aftereffect. In the absence of fixational eye movements, visual perception may fade out or disappear due to neural adaptation. (See
Adaptation (eye)
In visual physiology, adaptation is the ability of the retina of the eye to adjust to various levels of light. Natural night vision, or scotopic vision, is the ability to see under low-light conditions. In humans, rod cells are exclusively resp ...
). When an observer's visual stream adapts to a single direction of real motion, imagined motion can be perceived at various speeds. If the imagined motion is in the same direction as that experienced during adaptation, imagined speed is slowed; when imagined motion is in the opposite direction, its speed is increased; when adaptation and imagined motions are orthogonal, imagined speed is unaffected. Studies using magnetoencephalography (MEG) have demonstrated that subjects exposed to a repeated visual stimulus at brief intervals become attenuated to the stimulus in comparison to the initial stimulus. The results revealed that visual responses to the repeated compared with novel stimulus showed a significant reduction in both activation strength and peak latency but not in the duration of neural processing.
Although motion and images are extremely important regarding adaptation, the most important adaptation is adjusting to brightness levels. On entering a dark room or a very brightly lit room it takes a little while to adjust to the different levels. Adjusting to brightness levels allows mammals to detect changes in their surrounding. This is called
dark adaptation
Darkness, the direct opposite of lightness, is defined as a lack of illumination, an absence of visible light, or a surface that absorbs light, such as black or brown.
Human vision is unable to distinguish colors in conditions of very low l ...
.
Auditory
Auditory adaptation, as perceptual adaptation with other senses, is the process by which individuals adapt to sounds and noises. As research has shown, as time progresses, individuals tend to adapt to sounds and tend to distinguish them less frequently after a while. Sensory adaptation tends to blend sounds into one, variable sound, rather than having several separate sounds as a series. Moreover, after repeated perception, individuals tend to adapt to sounds to the point where they no longer consciously perceive it, or rather, "block it out". An individual that lives close to the train tracks, will eventually stop noticing the sounds of passing trains. Similarly, individuals living in larger cities no longer notice traffic sounds after a while. Moving to a completely different area, such as a quiet countryside, that individual would then be aware of the silence, crickets, etc.
The mechanoreception of sound requires a specific set of receptor cells called
hair cell
Hair cells are the sensory receptors of both the auditory system and the vestibular system in the ears of all vertebrates, and in the lateral line organ of fishes. Through mechanotransduction, hair cells detect movement in their environment. ...
s that allow for gradient signals to pass onto spatial ganglia where the signal will be sent to the brain to be processed. Since this is mechanoreception, different from chemoreception, adaptation of sound from surroundings highly depends on the physical movement of opening and closing of cation channels on the hair cell stereocilia. Mechanoelectric transduction (MET) channels, located at the tops of stereocilia, are poised to detect tension induced by hair bundle deflection. Hair bundle deflection generates a force by pulling on
tip link
Tip links are extracellular filaments that connect stereocilia to each other or to the kinocilium in the hair cells of the inner ear.Pickles JO, Comis SD, Osborne MP. 1984.Cross-links between stereocilia in the guinea pig organ of Corti, and thei ...
proteins connecting adjacent stereocilia.
Olfactory
Perceptual adaptation is a phenomenon that occurs for all of the senses, including smell and touch. An individual can adapt to a certain smell with time. Smokers, or individuals living with smokers, tend to stop noticing the smell of cigarettes after some time, whereas people not exposed to smoke on a regular basis will notice the smell instantly. The same phenomenon can be observed with other types of smell, such as perfume, flowers, etc. The human brain can distinguish smells that are unfamiliar to the individual, while adapting to those it is used to and no longer require to be consciously recognized.
Olfactory neurons utilize a feedback system from the levels of Ca
2+ions to activate its adaptation to prolonged smells. Due to the fact that the olfactory signal transduction uses a second messenger transduction system, the
mechanism
Mechanism may refer to:
*Mechanism (engineering), rigid bodies connected by joints in order to accomplish a desired force and/or motion transmission
*Mechanism (biology), explaining how a feature is created
*Mechanism (philosophy), a theory that a ...
of adaptation includes several factors that mostly include CaMK or
calmodulin
Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the bind ...
bound to Ca
2+ions.
Somatosensory
This phenomenon also applies to the sense of touch. An unfamiliar piece of clothing that was just put on will be noticed instantly; however, once it has been worn for a while, the mind will adapt to its texture and ignore the stimulus.
Pain
While large mechanosensory neurons such as type I/group Aß display adaptation, smaller type IV/group C nociceptive neurons do not. As a result, pain does not usually subside rapidly but persists for long periods of time; in contrast, other sensory information is quickly adapted to, if surroundings remain constant.
Weight training
Studies have shown that there is neural adaptation after as little as one weight training session. Strength gains are experienced by subjects without any increased muscle size. Muscle surface recordings using
electromyographic (SEMG) techniques have found that early strength gains throughout training are associated with increased amplitude in SEMG activity. These findings along with various other theories explain increases in strength without increases in muscle mass. Other theories for increases in strength relating to neural adaptation include:
agonist-antagonist
In pharmacology the term agonist-antagonist or mixed agonist/antagonist is used to refer to a drug which under some conditions behaves as an agonist (a substance that fully activates the receptor that it binds to) while under other conditions, beh ...
muscle decreased co-activation,
motor unit
A motor unit is made up of a motor neuron and all of the skeletal muscle fibers innervated by the neuron's axon terminals, including the neuromuscular junctions between the neuron and the fibres. Groups of motor units often work together as a mot ...
synchronization, and motor unit increased
firing rates.
Neural adaptations contribute to changes in V-waves and
Hoffmann's reflex
Hoffmann's reflex (Hoffmann's sign, sometimes simply "''Hoffmann's''", also finger flexor reflex) is a neurological examination finding elicited by a reflex test which can help verify the presence or absence of issues arising from the corticospinal ...
. H-reflex can be used to assess the excitability of spinal
α-motoneurons, whereas V-wave measures the magnitude of motor output from α-motoneurons. Studies showed that after a 14-week resistance training regime, subjects expressed V-wave amplitude increases of ~50% and H-reflex amplitude increases of ~20%. This showed that neural adaptation accounts for changes to functional properties of the spinal cord circuitry in humans without affecting organization of the
motor cortex
The motor cortex is the region of the cerebral cortex believed to be involved in the planning, control, and execution of voluntary movements.
The motor cortex is an area of the frontal lobe located in the posterior precentral gyrus immediately a ...
.
Habituation vs. adaptation
The terms neural adaptation and
habituation
Habituation is a form of non-associative learning in which an innate (non-reinforced) response to a stimulus decreases after repeated or prolonged presentations of that stimulus. Responses that habituate include those that involve the intact org ...
are often confused for one another. Habituation is a behavioral phenomenon while neural adaptation is a physiological phenomenon, although the two are not entirely separate. During habituation, one has some conscious control over whether one notices something to which one is becoming habituated. However, when it comes to neural adaptation, one has no conscious control over it. For example, if one has adapted to something (like an odor or perfume), one can not consciously force themselves to smell that thing. Neural adaptation is tied very closely to stimulus intensity; as the intensity of a light increases, one's senses will adapt more strongly to it. In comparison, habituation can vary depending on the stimulus. With a weak stimulus habituation can occur almost immediately but with a strong stimulus the animal may not habituate at all e.g. a cool breeze versus a fire alarm. Habituation also has a set of characteristics that must be met to be termed a habituation process.
Rhythmic behaviors
Short-term adaptations
Short term neural adaptations occur in the body during
rhythm
Rhythm (from Greek , ''rhythmos'', "any regular recurring motion, symmetry") generally means a " movement marked by the regulated succession of strong and weak elements, or of opposite or different conditions". This general meaning of regular recu ...
ic activities. One of the most common activities when these neural adaptations are constantly happening is walking.
As a person walks, the body constantly gathers information about the environment and the surroundings of the feet, and slightly adjusts the muscles in use according to the
terrain
Terrain or relief (also topographical relief) involves the vertical and horizontal dimensions of land surface. The term bathymetry is used to describe underwater relief, while hypsometry studies terrain relative to sea level. The Latin word ...
. For example, walking uphill requires different muscles than walking on flat pavement. When the brain recognizes that the body is walking uphill, it makes neural adaptations that send more activity to muscles required for uphill walking.
The rate of neural adaptation is affected by the area of the brain and by the similarity between sizes and shapes of previous stimuli. Adaptations in the
inferior temporal gyrus
The inferior temporal gyrus is one of three gyri of the temporal lobe and is located below the middle temporal gyrus, connected behind with the inferior occipital gyrus; it also extends around the infero-lateral border on to the inferior surface o ...
are very dependent on previous stimuli being of similar size, and somewhat dependent on previous stimuli being of a similar shape. Adaptations in the
prefrontal cortex
In mammalian brain anatomy, the prefrontal cortex (PFC) covers the front part of the frontal lobe of the cerebral cortex. The PFC contains the Brodmann areas BA8, BA9, BA10, BA11, BA12, BA13, BA14, BA24, BA25, BA32, BA44, BA45, BA46, ...
are less dependent on previous stimuli being of similar size and shape.
Long-term adaptations
Some rhythmic movements, such as respiratory movements, are essential for survival. Because these movements must be used over the course of the entire lifetime, it is important for them to function optimally. Neural adaptation has been observed in these movements in response to training or altered external conditions.
Animals have been shown to have reduced breathing rates in response to better fitness levels. Since breathing rates were not conscious changes made by the animal, it is presumed that neural adaptations occur for the body to maintain a slower breathing rate.
Transcranial magnetic stimulation
Transcranial magnetic stimulation
Transcranial magnetic stimulation (TMS) is a noninvasive form of brain stimulation in which a changing magnetic field is used to induce an electric current at a specific area of the brain through electromagnetic induction. An electric pulse gener ...
(TMS) is an important technique in modern
cognitive neuropsychology
Cognitive neuropsychology is a branch of cognitive psychology that aims to understand how the structure and function of the brain relates to specific psychological processes. Cognitive psychology is the science that looks at how mental processes ...
that is used to investigate the perceptual and behavioral effects of temporary interference of neural processing. Studies have shown that when a subject's visual cortex is disrupted by TMS, the subject views colorless flashes of light, or
phosphenes
A phosphene is the phenomenon of seeing light without light entering the eye. The word ''phosphene'' comes from the Greek words ''phos'' (light) and ''phainein'' (to show). Phosphenes that are induced by movement or sound may be associated wit ...
. When a subjects’ vision was subjected to the constant stimulus of a single color, neural adaptations occurred that made the subjects used to the color. Once this adaptation had occurred, TMS was used to disrupt the subjects’ visual cortex again, and the flashes of light viewed by the subject were the same color as the constant stimulus before the disruption.
Drug induced
Neural adaptation can occur for other than natural means. Antidepressant drugs, such as those that cause down regulation of β-
adrenergic receptors
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta ...
, can cause rapid neural adaptations in the brain. By creating a quick adaptation in the regulation of these receptors, it is possible for drugs to reduce the effects of stress on those taking the medication.
Post-injury
Neural adaptation is often critical for an animal's survival after an injury. In the short-term, it may alter an animal's movements so as to prevent worsening the injury. In the long-term, it may enable the animal's full or partial recovery from the injury.
Brain injury
Studies in children with early childhood brain injuries have shown that neural adaptations slowly occur after the injury. Children with early injuries to the
linguistics
Linguistics is the scientific study of human language. It is called a scientific study because it entails a comprehensive, systematic, objective, and precise analysis of all aspects of language, particularly its nature and structure. Linguis ...
, spatial cognition and
affective
Affect, in psychology, refers to the underlying experience of feeling, emotion or mood.
History
The modern conception of affect developed in the 19th century with Wilhelm Wundt. The word comes from the German ''Gefühl'', meaning "feeling."
...
development areas of the brain showed deficits in those areas as compared to those without injury. Due to neural adaptations, however, by early school-age, considerable development to those areas was observed.
Leg injury
After the amputation of a front leg, the fruit fly (
''Drosophila'' ''melanogaster'') shows immediate changes in body position and walking kinematics that enable it to continue walking.
The fruit fly exhibits longer-term adaptations as well. Researchers found that immediately after amputating a hind leg, flies favored turning away from the side of the injury, but that after several days this bias went away, and the flies turned left and right evenly, as they had before the injury.
These researchers compared flies with functioning versus impaired
proprioception
Proprioception ( ), also referred to as kinaesthesia (or kinesthesia), is the sense of self-movement, force, and body position. It is sometimes described as the "sixth sense".
Proprioception is mediated by proprioceptors, mechanosensory neurons ...
— the body's sense of where it is in space — and found that without proprioception, flies did not exhibit the same recovery from a turning bias after injury.
This result indicates that proprioceptive information is necessary for some of the neural adaptation that occurs in ''Drosophila'' after a leg injury.
See also
*
Acclimatization (neurons) Acclimatisation is the process by which the nervous system fails to respond to a stimulus, as a result of the repeated stimulation of a transmission across a synapse. Acclimatisation is believed to occur when the synaptic knob of the presynaptic neu ...
, the process by which neural adaptation is usually believed to occur
*
Adaptive system
An adaptive system is a set of interacting or interdependent entities, real or abstract, forming an integrated whole that together are able to respond to environmental changes or changes in the interacting parts, in a way analogous to either conti ...
*
fMRIa
Functional magnetic resonance imaging adaptation (FMRIa) is a method of functional magnetic resonance imaging that reads the brain changes occurring in response to long exposure to evocative stimulus.{{Cite journal, last=Grill-Spector, first=Kal ...
References
{{reflist
Cognitive neuroscience
Developmental neuroscience
Perception
Sensory systems