In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, an aerobactin synthase () is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
:4 ATP + citrate + 2 N
6-acetyl-N
6-hydroxy-L-lysine + 2 H
2O
4 ADP + 4 phosphate +
aerobactin
Aerobactin is a bacterial iron chelating agent (siderophore) found in ''E. coli''. It is a virulence factor enabling ''E. coli'' to sequester iron in iron-poor environments such as the urinary tract.
Aerobactin is biosynthesized by the oxidation ...
The 4
substrates of this enzyme are
ATP
ATP may refer to:
Companies and organizations
* Association of Tennis Professionals, men's professional tennis governing body
* American Technical Publishers, employee-owned publishing company
* ', a Danish pension
* Armenia Tree Project, non ...
,
citrate,
N6-acetyl-N6-hydroxy-L-lysine, and
H2O, whereas its 3
products are
ADP
Adp or ADP may refer to:
Aviation
* Aéroports de Paris, airport authority for the Parisian region in France
* Aeropuertos del Perú, airport operator for airports in northern Peru
* SLAF Anuradhapura, an airport in Sri Lanka
* Ampara Air ...
,
phosphate
In chemistry, a phosphate is an anion, salt, functional group or ester derived from a phosphoric acid. It most commonly means orthophosphate, a derivative of orthophosphoric acid .
The phosphate or orthophosphate ion is derived from phospho ...
, and
aerobactin
Aerobactin is a bacterial iron chelating agent (siderophore) found in ''E. coli''. It is a virulence factor enabling ''E. coli'' to sequester iron in iron-poor environments such as the urinary tract.
Aerobactin is biosynthesized by the oxidation ...
.
This enzyme belongs to the family of
ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The
systematic name of this enzyme class is citrate:N
6-acetyl-N
6-hydroxy-L-lysine ligase (ADP-forming). This enzyme is also called citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming). This enzyme participates in
lysine degradation.
References
*
*
*
*
*
EC 6.3.2
Enzymes of unknown structure
{{6.3-enzyme-stub