Adrenergic release inhibitors are a class of drugs which inhibit the release of epinephrine (adrenaline) and/or

norepinephrine Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as both a hormone and neurotransmitter. The name "noradrenaline" (from Latin '' ad' ...

(noradrenaline) from

adrenergic Adrenergic means "working on adrenaline (epinephrine) or noradrenaline (norepinephrine)" (or on their receptors). When not further qualified, it is usually used in the sense of enhancing or mimicking the effects of epinephrine and norepinephrine ...

nerve terminals and are used as

antihypertensive Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests tha ...

s. Examples of these agents include bethanidine,

bretylium Bretylium (also bretylium tosylate) is an antiarrhythmic agent. It blocks the release of noradrenaline from nerve terminals. In effect, it decreases output from the peripheral sympathetic nervous system. It also acts by blocking K+ channels and is ...

, debrisoquine, guanadrel,

guanazodine Guanazodine is a hypotensive sympatholytic drug. References Adrenergic release inhibitors Azocanes Guanidines {{antihypertensive-stub ...

, guancydine, guanethidine, guanoclor, and guanoxan. Most agents of this class are

guanidinium Guanidine is the compound with the formula HNC(NH2)2. It is a colourless solid that dissolves in polar solvents. It is a strong base that is used in the production of plastics and explosives. It is found in urine predominantly in patients experie ...

compounds and have little capacity to cross the blood–brain barrier.

References

{{Sympatholytic antihypertensives Adrenergic release inhibitors