Adolph Strecker (21 October 1822 – 7 November 1871) was a German
chemist
A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a graduated scientist trained in the study of chemistry, or an officially enrolled student in the field. Chemists study the composition of ...
who is known primarily for his work with
amino acids
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the Proteinogenic amino acid, 22 α-amino acids incorporated into p ...
.
Life and work
Strecker was born in Darmstadt, the son of Friedrich Ludwig Strecker, an
archivist
An archivist is an information professional who assesses, collects, organizes, preserves, maintains control over, and provides access to records and archives determined to have long-term value. The records maintained by an archivist can cons ...
working for the hessian
Grand Duke
Grand duke (feminine: grand duchess) is a European hereditary title, used either by certain monarchs or by members of certain monarchs' families. The title is used in some current and former independent monarchies in Europe, particularly:
* in ...
, and Henriette Amalie Johannette Koch. Adolph Strecker attended school in Darmstadt until 1838 when he changed to the higher Gewerbeschule. After receiving his abitur in 1840, Strecker began studying science at the
University of Giessen
University of Giessen, official name Justus Liebig University Giessen (), is a large public research university in Giessen, Hesse, Germany. It is one of the oldest institutions of higher education in the German-speaking world. It is named afte ...
, where
Justus Liebig was a professor. In August 1842, Strecker received his PhD and began teaching at a
realschule
Real school (, ) is a type of secondary school in Germany, Switzerland and Liechtenstein. It has also existed in Croatia (''realna gimnazija''), the Austrian Empire, the German Empire, Denmark and Norway (''realskole''), Sweden (''realskola''), F ...
in Darmstadt. He refused one offer to work for Liebig, but in 1846 he accepted another and became Liebig's private assistant at the University of Giessen. Strecker finished his habilitation in 1848 and became a lecturer at the university.
Strecker investigated a wide variety of problems in both organic and inorganic chemistry during his time at Giessen. Examples include the molecular masses of
silver
Silver is a chemical element; it has Symbol (chemistry), symbol Ag () and atomic number 47. A soft, whitish-gray, lustrous transition metal, it exhibits the highest electrical conductivity, thermal conductivity, and reflectivity of any metal. ...
and
carbon
Carbon () is a chemical element; it has chemical symbol, symbol C and atomic number 6. It is nonmetallic and tetravalence, tetravalent—meaning that its atoms are able to form up to four covalent bonds due to its valence shell exhibiting 4 ...
, the reactions of
lactic acid
Lactic acid is an organic acid. It has the molecular formula C3H6O3. It is white in the solid state and it is miscible with water. When in the dissolved state, it forms a colorless solution. Production includes both artificial synthesis as wel ...
, the decomposition of
hippuric acid
Hippuric acid (Greek language, Gr. ''hippos'', horse, ''ouron'', urine) is a carboxylic acid and organic compound. It is found in urine and is formed from the combination of benzoic acid and glycine. Levels of hippuric acid rise with the consumpt ...
by
nitric acid
Nitric acid is an inorganic compound with the formula . It is a highly corrosive mineral acid. The compound is colorless, but samples tend to acquire a yellow cast over time due to decomposition into nitrogen oxide, oxides of nitrogen. Most com ...
, and the separation of
cobalt
Cobalt is a chemical element; it has Symbol (chemistry), symbol Co and atomic number 27. As with nickel, cobalt is found in the Earth's crust only in a chemically combined form, save for small deposits found in alloys of natural meteoric iron. ...
and
nickel
Nickel is a chemical element; it has symbol Ni and atomic number 28. It is a silvery-white lustrous metal with a slight golden tinge. Nickel is a hard and ductile transition metal. Pure nickel is chemically reactive, but large pieces are slo ...
.
Strecker wanted to leave Giessen for a position at the
University of Berlin
The Humboldt University of Berlin (, abbreviated HU Berlin) is a public research university in the central borough of Mitte in Berlin, Germany.
The university was established by Frederick William III on the initiative of Wilhelm von Humbol ...
, but when he heard of an open position at Norway's
University of Christiania, he applied for it and in 1851 became a professor there. While in Norway, Strecker focused on organic chemistry, covering a broad range of topics from organometallic chemistry to natural products.
Strecker left Norway on
Christian Gottlob Gmelin's death in 1860 to accept the latter's position at the
University of Tübingen
The University of Tübingen, officially the Eberhard Karl University of Tübingen (; ), is a public research university located in the city of Tübingen, Baden-Württemberg, Germany.
The University of Tübingen is one of eleven German Excellenc ...
. There he conducted research on
guanine
Guanine () (symbol G or Gua) is one of the four main nucleotide bases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine ( uracil in RNA). In DNA, guanine is paired with cytosine. The guanine nucleoside ...
,
xanthine
Xanthine ( or , from Ancient Greek for its yellowish-white appearance; archaically xanthic acid; systematic name 3,7-dihydropurine-2,6-dione) is a purine base found in most human body tissues and fluids, as well as in other organisms. Several ...
,
caffeine
Caffeine is a central nervous system (CNS) stimulant of the methylxanthine chemical classification, class and is the most commonly consumed Psychoactive drug, psychoactive substance globally. It is mainly used for its eugeroic (wakefulness pr ...
, and
theobromine
Theobromine, also known as xantheose, is the principal alkaloid of ''Theobroma cacao'' (cacao plant). Theobromine is slightly water-soluble (330 mg/L) with a bitter taste. In industry, theobromine is used as an additive and precursor to ...
, and on the very toxic
thallium
Thallium is a chemical element; it has Symbol (chemistry), symbol Tl and atomic number 81. It is a silvery-white post-transition metal that is not found free in nature. When isolated, thallium resembles tin, but discolors when exposed to air. Che ...
oxides, which damaged his health severely. He moved to the
University of Würzburg
The Julius Maximilian University of Würzburg (also referred to as the University of Würzburg, in German ''Julius-Maximilians-Universität Würzburg'') is a public research university in Würzburg, Germany. Founded in 1402, it is one of the ol ...
in 1870, but his first semester was interrupted by the
Franco-Prussian War
The Franco-Prussian War or Franco-German War, often referred to in France as the War of 1870, was a conflict between the Second French Empire and the North German Confederation led by the Kingdom of Prussia. Lasting from 19 July 1870 to 28 Janua ...
of 1870–1871. Strecker became an officer during the war and returned to the university after it, where he started his last semester. In the summer of 1871 he undertook a recreational holiday in
Berchtesgaden
Berchtesgaden () is a municipality in the district Berchtesgadener Land, Bavaria, in southeastern Germany, near the border with Austria, south of Salzburg and southeast of Munich. It lies in the Berchtesgaden Alps. South of the town, the Be ...
,
Bavaria
Bavaria, officially the Free State of Bavaria, is a States of Germany, state in the southeast of Germany. With an area of , it is the list of German states by area, largest German state by land area, comprising approximately 1/5 of the total l ...
, but his health began to deteriorate. Strecker died in
Würzburg
Würzburg (; Main-Franconian: ) is, after Nuremberg and Fürth, the Franconia#Towns and cities, third-largest city in Franconia located in the north of Bavaria. Würzburg is the administrative seat of the Regierungsbezirk Lower Franconia. It sp ...
, where he is buried in the Hauptfriedhof.
Strecker synthesis
The
Strecker synthesis of amino acids involves the reaction of
potassium cyanide
Potassium cyanide is a compound with the formula KCN. It is a colorless salt, similar in appearance to sugar, that is highly soluble in water. Most KCN is used in gold mining, organic synthesis, and electroplating. Smaller applications include ...
,
ammonium chloride
Ammonium chloride is an inorganic chemical compound with the chemical formula , also written as . It is an ammonium salt of hydrogen chloride. It consists of ammonium cations and chloride anions . It is a white crystalline salt (chemistry), sal ...
, and an aldehyde to make an alpha amino acid. The reaction can also be run with ammonia, hydrogen cyanide, and an aldehyde.
Because of the relative simplicity of the reactants, the Strecker synthesis has been invoked by those studying both the origin of life and meteoritic amino acids.
Also named for Strecker are the
Strecker degradation, which involves the conversion of amino acids into imines and then to aldehydes, and the
Strecker sulfite alkylation.
Notable people who taught Strecker
*
Justus von Liebig
Justus ''Freiherr'' von Liebig (12 May 1803 – 18 April 1873) was a Germans, German scientist who made major contributions to the theory, practice, and pedagogy of chemistry, as well as to agricultural and biology, biological chemistry; he is ...
(1803–1873)
Notable students of Strecker
*
Georg Zehfuss (de) (1832–1901)
Family
Strecker, while serving as a professor in Norway, returned to Germany for several holidays. During one such visit to Darmstadt, Strecker, on July 3, 1852, married Karoline Auguste Natalie Weber (1852–1853), who died months later – on October 13, 1853. She had given birth on October 2, 1853, to Friederike Caroline Sophie Christiane Natalie Strecker. Adolph Stecker married a second time on September 29, 1855.
References
External links
Adolph Strecker obituaryby Rudolf Wagner from ''Berichte der Deutschen Chemischen Gesellschaft'', 1872, part V, pp. 125–131
* Obituary in the ''Journal of the Chemical Society'', 1872, volume 25, p. 353
* Adolph Strecker by B. Lepsius (1892), ''Allgemeine Deutsche Biographie'', volume 36, Leipzig: Duncker & Humblot – entry for Strecker
– brief biography and two pictures at Tübingen University
* ''Regnault-Strecker's kurzes Lehrbuch der Chemie''. Vieweg, Braunschweig 185
Digital editionby the
University and State Library Düsseldorf
The University and State Library Düsseldorf (, abbreviated ULB Düsseldorf) is a central service institution of Heinrich Heine University. Along with Bonn and Münster, it is also one of the three State Libraries of North Rhine-Westphalia.
...
*
2. Organische Chemie. 1853*
1. Anorganische Chemie. 3., verb. Aufl. 1855*
2. Organische Chemie. 2. Aufl.1857*
1. Anorganische Chemie. 4. Aufl.1858*
1. Anorganische Chemie. 9., neu bearb. Aufl. / von Johannes Wislicenus. 1877
{{DEFAULTSORT:Strecker, Adolph
Academic staff of the University of Würzburg
Academic staff of the University of Tübingen
19th-century German chemists
University of Giessen alumni
Academic staff of the University of Oslo
1822 births
1871 deaths
Scientists from Darmstadt