Adenosquamous carcinoma is a type of
cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...
that contains two types of cells:
squamous
Epithelium or epithelial tissue is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. It is a thin, continuous, protective layer of compactly packed cells with a little intercellula ...
cells (thin, flat cells that line certain organs) and gland-like cells. It has been associated with more aggressive characteristics when compared to adenocarcinoma in certain cancers.
It is responsible for 1% to 4% of exocrine forms of
pancreas cancer
Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass. These cancerous cells have the ability to invade other parts of the body. A number of types of pancre ...
.
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Diagnosis
Light microscopy shows a combination of gland-like cells and squamous
epithelial
Epithelium or epithelial tissue is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. It is a thin, continuous, protective layer of compactly packed cells with a little intercell ...
cells.
[ ] On
immunohistochemistry, it is typically positive for
CK5/6 Cytokeratin 5/6 antibodies are antibodies that target both cytokeratin 5 and cytokeratin 6. Topic Completed: 3 June 2019. Revised: 8 December 2019 These are used in immunohistochemistry, often called CK 5/6 staining, including the following applic ...
,
CK7 and
p63, and negative for
CK20
Keratin 20, often abbreviated CK20, is a protein that in humans is encoded by the ''KRT20'' gene.
Keratin 20 is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric ...
,
p16
p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S p ...
and
p53
p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often s ...
. On
genetic testing,
KRAS
''KRAS'' ( Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cel ...
and
p53
p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often s ...
are typically altered.
References
External links
Adenosquamous carcinomaentry in the public domain NCI Dictionary of Cancer Terms
Carcinoma
Infectious causes of cancer
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