Adam P. Geballe is an American microbiologist and an Elected Fellow of the

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...

. Currently, he is a Professor at

University of Washington The University of Washington (UW, simply Washington, or informally U-Dub) is a public research university in Seattle, Washington. Founded in 1861, Washington is one of the oldest universities on the West Coast; it was established in Seattle a ...

, an investigator at Fred Hutchinson Cancer Research Center, and a physician at

Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment and research center in Seattle, Washington. Established in 1998, this nonprofit provides clinical oncology care for patients treated at its three partner organizations: Fred Hutchinson Can ...

Biography

Geballe is the son of Frances "Sissy" (née Koshland) and Theodore H. Geballe. His father is a physicist and his mother is the daughter of Daniel E. Koshland Sr. of the Haas family, owners of Levi Strauss & Co. He has five siblings: Gordon Theodore Geballe, Alison Frances Geballe, Monica Thompson, Jennifer Geballe Norman, and Ernest Henry Geballe. He earned his B.A. at

Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...

and his M.D. at

Duke University Duke University is a private research university in Durham, North Carolina. Founded by Methodists and Quakers in the present-day city of Trinity in 1838, the school moved to Durham in 1892. In 1924, tobacco and electric power industrialist James ...

Research

Adam Geballe's research has primarily focused on the mechanisms used by

human cytomegalovirus ''Human betaherpesvirus 5'', also called human cytomegalovirus (HCMV), is species of virus in the genus ''Cytomegalovirus'', which in turn is a member of the viral family known as ''Herpesviridae'' or herpesviruses. It is also commonly called ...

to evade the

host A host is a person responsible for guests at an event or for providing hospitality during it. Host may also refer to: Places * Host, Pennsylvania, a village in Berks County People *Jim Host (born 1937), American businessman * Michel Host ...

immune response. In particular, his group has identified and characterized the process by which the viral proteins pTRS1 and pIRS1 interfere with the host sensing of RNA mediated by the sensor PKR. Additionally, his group researches

poxvirus ''Poxviridae'' is a family of double-stranded DNA viruses. Vertebrates and arthropods serve as natural hosts. There are currently 83 species in this family, divided among 22 genera, which are divided into two subfamilies. Diseases associated wit ...

evasion of host immune responses, as well as various aspects of how viruses interact with host translational machinery. His most cited paper is ''Upstream open reading frames as regulators of mRNA translation'',

Publications

*A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists. Carpentier KS, Esparo NM, Child SJ, Geballe AP PLOS Pathogens. 2016 Oct; 12 10: e1005966 *The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA. Gray EE, Winship D, Snyder JM, Child SJ, Geballe AP, Stetson DB Immunity. 2016 08; 45 2: 255-66 *Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals. Daugherty MD, Schaller AM, Geballe AP, Malik HS eLife. 2016 May; 5 *An Evolutionary View of the Arms Race between Protein Kinase R and Large DNA Viruses. Carpentier KS, Geballe AP Journal of Virology. 2016 Jan; 90 7: 3280-3 *Essential role of protein kinase R antagonism by TRS1 in human cytomegalovirus replication. Braggin JE, Child SJ, Geballe AP Virology. 2016 Feb; 489 : 75-85

References

{{DEFAULTSORT:Geballe, Adam Living people Fellows of the American Association for the Advancement of Science University of Washington faculty American microbiologists Jewish American scientists Haas family 1951 births Fred Hutchinson Cancer Research Center people