Adafenoxate is a compound related to
centrophenoxine
Meclofenoxate (INN, BAN; brand name Lucidril, also known as centrophenoxine) is a cholinergic nootropic used as a dietary supplement. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).
In elderly patients, me ...
, that has been found to act as a
nootropic
Nootropics ( , or ) (colloquial: smart drugs and cognitive enhancers, similar to adaptogens) are a wide range of natural or synthetic supplements or drugs and other substances that are claimed to improve cognitive function or to promote re ...
in rats.
Synthesis
Ex 1: 4-Chlorophenoxyacetic acid (pCPA)
22-88-3is converted to its acid chloride to give 4-chlorophenoxyacetyl chloride
122-68-3(1). Esterification with 2-(1-adamantylamino)ethanol
716-66-3(2) gives Adafenoxate (3) in a single step.
Ex 2: Same as above but
Fischer–Speier esterification
Fischer esterification or Fischer–Speier esterification is a special type of esterification by refluxing a carboxylic acid and an alcohol in the presence of an acid catalyst. The reaction was first described by Emil Fischer and Arthur Speier ...
done via a DS-trap. This gives an 88% yield.
References
Adamantanes
Chloroarenes
Cholinergics
Amines
Nootropics
Phenoxyacetic acids
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