The enzyme acetylajmaline esterase (EC 3.1.1.80, AAE, 2β(''R'')-17-''O''-acetylajmalan:acetylesterase, acetylajmalan esterase; systematic name 17-''O''-acetylajmaline ''O''-acetylhydrolase)
the following reactions:
: (1) 17-''O''-acetylajmaline + H
2O
ajmaline
Ajmaline (also known by trade names Gilurytmal, Ritmos, and Aritmina) is an alkaloid that is classified as a 1-A antiarrhythmic agent. It is often used to induce arrhythmic contraction in patients suspected of having Brugada syndrome. Individuals ...
+
acetate
: (2) 17-''O''-acetylnorajmaline + H
2O
norajmaline + acetate
This plant enzyme mediates the last stages in the
biosynthesis of the
indole alkaloid
Indole alkaloids are a class of alkaloids containing a structural moiety of indole; many indole alkaloids also include isoprene groups and are thus called terpene indole or secologanin tryptamine alkaloids. Containing more than 4100 known diffe ...
ajmaline
Ajmaline (also known by trade names Gilurytmal, Ritmos, and Aritmina) is an alkaloid that is classified as a 1-A antiarrhythmic agent. It is often used to induce arrhythmic contraction in patients suspected of having Brugada syndrome. Individuals ...
.
References
External links
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EC 3.1.1