Acetyl-CoA Hydrolase on:
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The enzyme acetyl-CoA hydrolase (EC 3.1.2.1) 
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the reaction
acetyl-CoA + H2O CoA + acetate
This enzyme belongs to the family of hydrolases, specifically those acting on thioester
In organic chemistry, thioesters are organosulfur compounds with the functional group . They are analogous to carboxylate esters () with the sulfur in the thioester playing the role of the linking oxygen in the carboxylate ester, as implied by t ...
bonds. The systematic name is CoA thiol esterase. This enzyme participates in pyruvate metabolism
Pyruvic acid (CH3COCOOH) is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group. Pyruvate, the conjugate base
A conjugate acid, within the Brønsted–Lowry acid–base theory, is a chemical compoun ...
.
Structural studies
As of late 2007, only onestructure
A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects such as ...
has been solved for this class of enzymes, with the PDB accession code .
See also
*Acetyl-CoA synthetase
Acetyl-CoA synthetase (ACS) or Acetate—CoA ligase is an enzyme () involved in metabolism of acetate. It is in the ligase class of enzymes, meaning that it catalyzes the formation of a new chemical bond between two large molecules.
Reaction
The ...
and ACSS2, enzymes that perform the reverse reaction using ATP
References
* EC 3.1.2 Enzymes of known structure {{3.1-enzyme-stub