Asialoglycoprotein receptor 1 is a
protein that in humans is encoded by the ASGR1
gene.
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]
Function
This gene encodes a subunit of the
asialoglycoprotein receptor. This receptor is a
transmembrane protein that plays a critical role in serum
glycoprotein
Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycos ...
homeostasis by mediating the
endocytosis
Endocytosis is a cellular process in which substances are brought into the cell. The material to be internalized is surrounded by an area of cell membrane, which then buds off inside the cell to form a vesicle containing the ingested material. E ...
and
lysosomal degradation of glycoproteins with exposed terminal
galactose or
N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate
hepatic infection by multiple viruses including
hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a
hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced
transcript variants encoding multiple
isoforms have been observed for this gene.
References
Further reading
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