Histone chaperone ASF1A is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''ASF1A''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.
Interactions
ASF1A has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
TLK1
Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the ''TLK1'' gene.
Function
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in ...
,
TLK2
Serine/threonine-protein kinase tousled-like 2 is an enzyme that in humans is encoded by the ''TLK2'' gene.
Function
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved i ...
,
[ ]CHAF1B
Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the ''CHAF1B'' gene.
Function
Chromatin assembly factor I (CAF-1) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of ...
CHAF1A
Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the ''CHAF1A'' gene.
Function
Chromatin assembly factor I ( CAF-1) is a nuclear complex consisting of p50, p60 ( CHAF1B; MIM 601245), and p150 (CHAF1A) subunits th ...
.[
]
References
Further reading
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External links
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