ADP-ribosylation factor-like protein 2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''ARL2''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
* The ADP-ribosylation factor (ARF) genes are small GTP-binding proteins of the RAS superfamily. ARL2 is a member of a functionally distinct group of ARF-like genes.
* In photoreceptors, ARL2 participates in the trafficking of lipidated membrane-associated proteins.
* There is an evidence that increased activity of ARL2 protein is strongly correlated with increased
mitochondria fusion, while loss of ARL2 activity results in a decreased rate of fusion.
Interactions
ARL2 has been shown to
interact
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with
Protein unc-119 homolog
Uncoordinated-119 (Unc-119) is a protein that has been identified in ''C. elegans'', humans, mice, zebrafish, rabbits, pig, calf, monkey, and protozoa. They have been classified in the GMP phophodiesterase, delta superfamily. Unc-119 proteins are ...
,
TBCD
Tubulin-specific chaperone D is a protein that in humans is encoded by the ''TBCD'' gene.
Function
Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding inte ...
and
PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the ''PDE6D'' gene. PDE6D was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase (PDE) ...
.
References
External links
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Further reading
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