Rho GTPase activating protein 18 is a protein that in humans is encoded by the ''ARHGAP18'' gene. The gene is also known as ''MacGAP'' and ''bA307O14.2''. ARHGAP18 belongs to a family of

Rho GTPase The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found ...

-activating proteins that modulate cell signaling.

Model organisms

Model organism A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workin ...

s have been used in the study of ARHGAP18 function. A conditional knockout mouse line, called ''Arhgap18^{tm1a(KOMP)Wtsi}'' was generated as part of the

International Knockout Mouse Consortium The International Knockout Mouse Consortium (IKMC) is a scientific endeavour to produce a collection of mouse embryonic stem cell lines that together lack every gene in the genome, and then to distribute the cells to scientific researchers to crea ...

program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on mutant mice and one significant abnormality was observed. Fewer than expected homozygous mutant embryos were identified during gestation.

Model organisms

References

Further reading