Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''ARFGEF1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.
Interactions
ARFGEF1 has been shown to
interact
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with
FKBP2
FK506-binding protein 2 is a protein that in humans is encoded by the ''FKBP2'' gene.
Function
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes i ...
,
ARFGEF2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ''ARFGEF2'' gene.
Function
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein enc ...
and
PRKAR1A
cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the ''PRKAR1A'' gene.
Function
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activ ...
.
References
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