Amyloid-like protein 1, also known as APLP1, is a
protein that in humans is encoded by the ''APLP1''
gene.
APLP1 along with
APLP2 are important modulators of
glucose and
insulin
Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism o ...
homeostasis.
Function
This gene encodes a member of the highly conserved
amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by
secretase Secretases are enzymes that "snip" pieces off a longer protein that is embedded in the cell membrane. 300px, Processing of the amyloid-beta precursor protein Among other roles in the cell, secretases act on the amyloid-beta precursor protein (AP ...
s in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development.
Alternatively spliced transcript variants encoding different isoforms have been described.
APLP1 and
APLP2 double
knockout mice
A knockout mouse, or knock-out mouse, is a genetically modified mouse (''Mus musculus'') in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. They are importan ...
display
hypoglycemia and
hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.
References
External links
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