AP-4 complex subunit beta-1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''AP4B1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 (
AP4E1
AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the ''AP4E1'' gene.
Function
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways ...
), a medium chain, mu-4 (
AP4M1
AP-4 complex subunit mu-1 is a protein that in humans is encoded by the ''AP4M1'' gene.
Function
This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. Thi ...
), and a small chain, sigma-4 (
AP4S1
AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the ''AP4S1'' gene.
Function
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. ...
)
Interactions
AP4B1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
AP4M1
AP-4 complex subunit mu-1 is a protein that in humans is encoded by the ''AP4M1'' gene.
Function
This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. Thi ...
.
Clinical relevance
AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.
References
External links
*
PDBe-KBprovides an overview of all the structure information available in the PDB for Human AP-4 complex subunit beta-1
Further reading
*
*
*
*
*
*
*
*
*
{{gene-1-stub