AMG-333 is a drug which acts as a potent and selective blocker of the
TRPM8 ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of io ...
, which is the main receptor responsible for the sensation of
cold. It was developed as a potential treatment for
migraine
Migraine (, ) is a common neurological disorder characterized by recurrent headaches. Typically, the associated headache affects one side of the head, is pulsating in nature, may be moderate to severe in intensity, and could last from a few hou ...
.
See also
*
PF-05105679
*
RQ-00203078
References
Pyridines
Trifluoromethyl ethers
Amides
Fluoroarenes
Carboxylic acids
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