AM-855 (part of the
AM cannabinoid series) is an
analgesic
An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...
drug which is a
cannabinoid agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
. It is a derivative of Δ
8Tetrahydrocannabinol
Tetrahydrocannabinol (THC) is the principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant. Although the chemical formula for THC (C21H30O2) describes multiple isomers, the term ''THC'' ...
with a conformationally restricted side chain which has been bound into a fourth ring fused to the
aromatic
In chemistry, aromaticity is a chemical property of cyclic ( ring-shaped), ''typically'' planar (flat) molecular structures with pi bonds in resonance (those containing delocalized electrons) that gives increased stability compared to satur ...
A-ring of the cannabinoid skeleton. AM-855 is an agonist at both
CB1 and
CB2 with moderate selectivity for CB
1, with a
Ki of 22.3 nM at CB
1 and 58.6 nM at CB
2.
References
AM cannabinoids
Benzochromenes
Phenols
{{cannabinoid-stub