Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase is an
enzyme that, in humans, is encoded by the ''ALG3''
gene.
This gene encodes a member of the ALG3 family. The encoded
protein catalyses the addition of the first
dol-P-Man
Dolichol monophosphate mannose is a chemical compound involved in glycosylation
Glycosylation is the reaction in which a carbohydrate (or ' glycan'), i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecu ...
derived
mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with
congenital disorder of
glycosylation
Glycosylation is the reaction in which a carbohydrate (or ' glycan'), i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor) in order to form a glycoconjugate. In biology (but not al ...
type Id (CDG-Id) characterized by abnormal
N-glycosylation.
References
Further reading
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External links
GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview*
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