ALC-0159 is a
PEG
PEG or peg may refer to:
Devices
* Clothes peg, a fastener used to hang up clothes for drying
* Tent peg, a spike driven into the ground for holding a tent to the ground
* Tuning peg, used to hold a string in the pegbox of a stringed instru ...
/lipid conjugate (i.e.
PEGylated
PEGylation (or pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein ...
lipid), specifically, it is the ''N,N''-di
myristylamide of
2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilo
dalton
Dalton may refer to:
Science
* Dalton (crater), a lunar crater
* Dalton (program), chemistry software
* Dalton (unit) (Da), the atomic mass unit
* John Dalton, chemist, physicist and meteorologist
Entertainment
* Dalton (Buffyverse), minor c ...
s (corresponding to about 45-46 ethylene oxide units per molecule of ''N,N''-dimyristyl hydroxyacetamide). It is a
non-ionic surfactant
Surfactants are chemical compounds that decrease the surface tension between two liquids, between a gas and a liquid, or interfacial tension between a liquid and a solid. Surfactants may act as detergents, wetting agents, emulsifiers, foa ...
by its nature. It has been deployed in the
Pfizer
Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfize ...
-
BioNTech
BioNTech SE ( ; or short for Biopharmaceutical New Technologies) is a German biotechnology company based in Mainz that develops and manufactures active immunotherapies for patient-specific approaches to the treatment of diseases. It develops ...
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19 (coronavirus disease 2019), the respiratory illness responsible for the ongoing COVID-19 pandemic. The virus previously had a No ...
mRNA vaccine
An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. The vaccine delivers molecules of antigen-encoding mRNA into immune cells, which use the designed mRNA as a bluepr ...
(0.05 mg per dose)
that contains the active ingredient
tozinameran.
See also
;Pfizer–BioNTech COVID-19 vaccine
nanoparticle
A nanoparticle or ultrafine particle is usually defined as a particle of matter that is between 1 and 100 nanometres (nm) in diameter. The term is sometimes used for larger particles, up to 500 nm, or fibers and tubes that are less than 10 ...
ingredients
*
ALC-0315
*
1,2-distearoyl-sn-glycero-3-phosphocholine
*
Cholesterol
Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell membr ...
;Others
*
Polyethoxylated tallow amine
References
Assessment report, Comirnaty, Common name: COVID-19 mRNA vaccine (nucleoside-modified); Procedure No. EMEA/H/C/005735/0000- gives structural formula for the compound (p. 24)
Lipids
Pfizer
Products introduced in 2020
Biotechnology
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