Aldo-keto reductase family 1 (AKR1) is a family of aldo-keto reductase

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

s that is involved in

steroid A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and a ...

metabolism Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cell ...

. It includes the AKR1C and AKR1D subgroups, which respectively consist of

AKR1C1 Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the ''AKR1C1'' gene. This gene encodes a member ...

– AKR1C4 and AKR1D1. Together with short-chain dehydrogenase/reductases (SDRs), these enzymes catalyze oxidoreductions, act on the C3, C5, C11, C17 and C20 positions of steroids, and function as , , 5β-reductases, , , and , respectively. The AKR1C enzymes act as 3-, 17- and 20- ketosteroid reductases, while AKR1D1 acts as the sole 5β-reductase in humans.

Members

AKR1A1; AKR1B1; AKR1B10;

;

AKR1C2 Aldo-keto reductase family 1 member C2, also known as bile acid binding protein, 3α-hydroxysteroid dehydrogenase type 3, and dihydrodiol dehydrogenase type 2, is an enzyme that in humans is encoded by the ''AKR1C2'' gene. This gene encodes a m ...

;

AKR1C3 Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a key steroidogenic enzyme that in humans is encoded by the ''AKR1C3'' gene. Function This gene encodes a member of t ...

; AKR1C4; AKR1D1; Others

References

Enzymes {{enzyme-stub

Members

See also

References