AGH-192 is a potent and selective, water soluble, orally bioavailable and brain penetrant full

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...

at the 5HT₇

serotonin Serotonin () or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vas ...

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

, derived from the older drug

AGH-107 AGH-107 is a potent, selective, water-soluble and brain penetrant full agonist at the 5HT7 serotonin receptor. AGH-107 is one of the few examples of low-basicity aminergic receptor agonists, which may underlie its high selectivity over the relat ...

. In animal tests it showed activity indicative of potential application in the treatment of neuropathic pain.

References

{{reflist Serotonin receptor agonists Indoles Iodoarenes Imidazoles

See also

References