An ADE model is a genetic model for
twin studies
Twin studies are studies conducted on identical or fraternal twins. They aim to reveal the importance of environmental and genetic influences for traits, phenotypes, and disorders. Twin research is considered a key tool in behavioral genetics a ...
which includes
dominance genetic effects.
Biometrical genetic modeling of twin or other family data can be used to decompose the variance of an observed response or
phenotype
In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological proper ...
into
genetic and
environmental
A biophysical environment is a biotic and abiotic surrounding of an organism or population, and consequently includes the factors that have an influence in their survival, development, and evolution. A biophysical environment can vary in scale f ...
components. Convenient
parametrizations requiring few random effects allow such models to be estimated using widely available
software
Software is a set of computer programs and associated documentation and data. This is in contrast to hardware, from which the system is built and which actually performs the work.
At the lowest programming level, executable code consists ...
for linear mixed models (continuous phenotypes) or
generalized linear mixed models (categorical phenotypes).
''A'' stands for
''additive'' genetic effects, ''D'' for non-additive genetic (or
''dominance'') effects, and ''E'' for nonshared ''environment'' effects.
[Douglas A. Raynor ''et al''. (2002). "Covariation of Psychosocial Characteristics Associated With Cardiovascular Disease: Genetic and Environmental Influences".]
See also
*
ACE model
References
Twin studies
Quantitative genetics
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