Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC
1, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''ADCYAP1R1''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
This receptor binds
pituitary adenylate cyclase activating peptide
Pituitary adenylate cyclase-activating polypeptide also known as PACAP is a protein that in humans is encoded by the ''ADCYAP1'' gene. pituitary adenylate cyclase-activating polypeptide is similar to vasoactive intestinal peptide. One of its effect ...
.
Function
PAC
1 is a membrane-associated protein and shares significant homology with members of the
G-protein coupled class B
glucagon/
secretin receptor
Human secretin receptor (gene name SCTR) is a G protein-coupled receptor which binds secretin and is the leading member (''i.e.'', first cloned) of the class B GPCR subfamily.
Interactions
Secretin receptor has been shown to interact with pitui ...
family.
This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase.
Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined.
PAC
1 is expressed in the
adrenal medulla,
pancreatic acini,
uterus
The uterus (from Latin ''uterus'', plural ''uteri'') or womb () is the organ in the reproductive system of most female mammals, including humans that accommodates the embryonic and fetal development of one or more embryos until birth. The ...
,
myenteric plexus and
brain
A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a ve ...
.
It is also expressed in the
trigeminal
In neuroanatomy, the trigeminal nerve ( lit. ''triplet'' nerve), also known as the fifth cranial nerve, cranial nerve V, or simply CN V, is a cranial nerve responsible for sensation in the face and motor functions such as biting and chewing; ...
,
otic and
superior cervical ganglia (prejunctional) and cerebral arteries (postjunctional).
References
Further reading
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External links
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{{Growth factor receptor modulators