ACP-105 is a drug which acts as a
selective androgen receptor modulator (SARM). It has been investigated for potential use in the treatment of
age-related cognitive decline.
The drug has been found to reduce
anxiety
Anxiety is an emotion which is characterized by an unpleasant state of inner turmoil and includes feelings of dread over anticipated events. Anxiety is different than fear in that the former is defined as the anticipation of a future threat wh ...
-like behavior in a
mouse model of
Alzheimer's disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me ...
when administered alone, as well as enhance
spatial memory
In cognitive psychology and neuroscience, spatial memory is a form of memory responsible for the recording and recovery of information needed to plan a course to a location and to recall the location of an object or the occurrence of an event. Sp ...
when coadministered with the
selective estrogen receptor β agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
AC-186.
ACP-105 is an
aniline
Aniline is an organic compound with the formula C6 H5 NH2. Consisting of a phenyl group attached to an amino group, aniline is the simplest aromatic amine
In organic chemistry, an aromatic amine is an organic compound consisting of an aroma ...
SARM and is related to
AC-262536 and
vosilasarm (RAD140).
References
Abandoned drugs
Chloroarenes
Heterocyclic compounds with 2 rings
Nitriles
Nitrogen heterocycles
Selective androgen receptor modulators
Tertiary alcohols
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