A45 or A-45 may refer to:
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A45 Infantry Support Tank, the chassis of which was developed into the Conqueror tank
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A45 Records, a German record label notably producing the band
Real McCoy
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Article 45 Concern Group, a political party in Hong Kong
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Indian Defence, Encyclopaedia of Chess Openings code
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A45 AMG, a performance compact car produced by Mercedes-Benz
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Sisu A-45, a Finnish military truck
;Roads
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A45 road, a road connecting Birmingham and Thrapston in England
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Autovía A-45, a road connecting Malaga and Cordoba in Spain
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Bundesautobahn 45, a road connecting Dortmund and Aschaffenburg in Germany
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A45 autoroute, a proposed motorway connecting Lyon and Saint-Étienne in France
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