A-84543 is a drug developed by Abbott, which acts as an agonist at neural

nicotinic acetylcholine receptor Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral ne ...

s with high selectivity for the α4β2 subtype. It is widely used in scientific research into the structure and function of this receptor subtype and has been the

lead compound A lead compound (, i.e. a "leading" compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical compound that has pharmacological or biological activity likely to be therapeutically useful, b ...

for the development of a large family of related derivatives.

References

Nicotinic agonists Aromatic ethers 3-Pyridyl compounds Pyrrolidines Stimulants {{nervous-system-drug-stub