A-68930 is a synthetic compound that acts as a selective
dopamine receptor
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through diffe ...
D1 agonist.
It is orally active and has
antidepressant and
anorectic
An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. By contrast, an appetite stimulant is referred to as orexigenic.
The term is (from the Greek ''ἀν-'' (an-) = "without" a ...
effects in animals, producing wakefulness and
tachycardia
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate. In general, a resting heart rate over 100 beats per minute is accepted as tachycardia in adults. Heart rates above the resting rate may be normal ( ...
,
but without
stimulant effects, instead producing
sedation.
The difference in effects between A-68930 and other D
1 agonists such as
SKF-82958
SKF-82,958 is a chemical synthesis, synthetic chemical compound, compound of the benzazepine chemical class, class that acts as a D1 receptor, D1/D5 receptor, D5 receptor full agonist. SKF-82,958 and similar D1-like-selective full agonists like S ...
may be due to their differing effects on the related
D5 receptor.
References
D1-receptor agonists
Isochromenes
Catechols
Phenylethanolamine ethers
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