AMDA (9-Aminomethyl-9,10-dihydroanthracene) is an
organic compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. The ...
which acts as a potent and selective
antagonist
An antagonist is a character in a story who is presented as the chief foe of the protagonist.
Etymology
The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, riv ...
for the
5-HT2A receptor
Receptor may refer to:
* Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...
.
It has been used to help study the shape of the 5-HT
2A protein, and develop a large family of related derivatives with even higher potency and selectivity.
Synthesis
It is synthesized from
9,10-Dihydroanthracene
9,10-Dihydroanthracene is an organic compound that is derived from the polycyclic aromatic hydrocarbon anthracene. Several isomers of dihydroanthracene are known, but the 9,10 derivative is most common. It is a colourless solid that is used as ...
. First one prepares the amide that is directly analogous to
Cyheptamide 199-29-3or to
Citenamide 0423-37-7 The last step in the synthesis is reduction of the amide functional group with
Borane-tetrahydrofuran.
See also
*Benzoctamine
Benzoctamine is a drug that possesses sedative and anxiolytic properties. Marketed as Tacitin by Ciba-Geigy, it is different from most sedative drugs because in most clinical trials it does not produce respiratory depression, but actually sti ...
References
5-HT2A antagonists
Phenethylamines
Anthracenes
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