72F fusion protein vaccine is a candidate
tuberculosis vaccine
Tuberculosis (TB) vaccines are vaccinations intended for the prevention of tuberculosis. Immunotherapy as a defence against TB was first proposed in 1890 by Robert Koch.Prabowo, S. et al. "Targeting multidrug-resistant tuberculosis (MDR-TB) by ...
created by
Statens Serum Institut (SSI). The 72F fusion protein is composed of the
Rv0125 and
Rv1196 proteins derived from ''
Mycobacterium tuberculosis
''Mycobacterium tuberculosis'' (M. tb) is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis. First discovered in 1882 by Robert Koch, ''M. tuberculosis'' has an unusual, waxy coating on its c ...
''.
Phase I clinical trials
The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases ...
were completed in 2005 and Phase II trials are awaited.
See also
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Fusion protein
Fusion proteins or chimeric (kī-ˈmir-ik) proteins (literally, made of parts from different sources) are proteins created through the joining of two or more genes that originally coded for separate proteins. Translation of this ''fusion gene'' r ...
References
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Tuberculosis vaccines
Protein subunit vaccines
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