7-methylguanosine 5'-phosphate
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7-Methylguanosine (m7G) is a modified
purine Purine is a heterocyclic compound, heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together. It is water-soluble. Purine also gives its name to the wider class of molecules, purines, which includ ...
nucleoside. It is a methylated version of guanosine and when found in human urine, it may be a biomarker of some types of cancer. In the
RNA Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...
s, 7-methylguanosine have been used to study and examine the reaction evolving methylguanosine. It also plays a role in
mRNA In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein. mRNA is ...
as a blocking group at its 5ยด-end.


See also

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METTL1 tRNA (guanine-N(7)-)-methyltransferase is an enzyme that in humans is encoded by the ''METTL1'' gene. This gene is similar in sequence to the Saccharomyces cerevisiae, S. cerevisiae YDL201w gene. The gene product contains a conserved S-Adenosyl me ...
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23S rRNA (guanine2445-N2)-methyltransferase 23S rRNA (guanine2445-N2)-methyltransferase (, ''ycbY (gene)'', ''rlmL (gene)'') is an enzyme with systematic name ''S-adenosyl-L-methionine:23S rRNA (guanine2445-N2)-methyltransferase''. This enzyme catalyses the following chemical reaction : S- ...
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16S rRNA (guanine527-N7)-methyltransferase 16S rRNA (guanine527-N7)-methyltransferase (, ''ribosomal RNA small subunit methyltransferase G'', ''16S rRNA methyltransferase RsmG'', ''GidB'', ''rsmG (gene)'') is an enzyme with systematic name ''S-adenosyl-L-methionine:16S rRNA (guanine527-N7)- ...


References


External links


Metabocard for 7-Methylguanosine (HMDB01107)
Human Metabolome Database, University of Alberta Nucleosides Purines Hydroxymethyl compounds Biomarkers {{organic-compound-stub