7-methylguanosine
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7-Methylguanosine (m7G) is a modified
purine Purine is a heterocyclic aromatic organic compound that consists of two rings ( pyrimidine and imidazole) fused together. It is water-soluble. Purine also gives its name to the wider class of molecules, purines, which include substituted purines ...
nucleoside Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleoti ...
. It is a
methylated In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group. Methylation is a form of alkylation, with a methyl group replacing a hydrogen atom. These ...
version of
guanosine Guanosine (symbol G or Guo) is a purine nucleoside comprising guanine attached to a ribose ( ribofuranose) ring via a β-N9- glycosidic bond. Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate ...
and when found in human urine, it may be a
biomarker In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues to examine normal biological processes, p ...
of some types of cancer. In the RNAs, 7-methylguanosine have been used to study and examine the reaction evolving methylguanosine. It also plays a role in
mRNA In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein. mRNA is created during the ...
as a blocking group at its 5´-end.


See also

*
METTL1 tRNA (guanine-N(7)-)-methyltransferase is an enzyme that in humans is encoded by the ''METTL1'' gene. This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif an ...
*
23S rRNA (guanine2445-N2)-methyltransferase 23S rRNA (guanine2445-N2)-methyltransferase (, ''ycbY (gene)'', ''rlmL (gene)'') is an enzyme with systematic name ''S-adenosyl-L-methionine:23S rRNA (guanine2445-N2)-methyltransferase''. This enzyme catalyses the following chemical reaction : S- ...
*
16S rRNA (guanine527-N7)-methyltransferase 16S rRNA (guanine527-N7)-methyltransferase (, ''ribosomal RNA small subunit methyltransferase G'', ''16S rRNA methyltransferase RsmG'', ''GidB'', ''rsmG (gene)'') is an enzyme with systematic name ''S-adenosyl-L-methionine:16S rRNA (guanine527-N7)- ...


References


External links


Metabocard for 7-Methylguanosine (HMDB01107)
Human Metabolome Database, University of Alberta Nucleosides Purines Hydroxymethyl compounds Biomarkers {{organic-compound-stub