7-ACA (7-aminocephalosporanic acid) is the core chemical structure (a
synthon
In retrosynthetic analysis, a synthon is a hypothetical unit within a target molecule that represents a potential starting reagent in the retroactive synthesis of that target molecule. The term was coined in 1967 by E. J. Corey. He noted in 1 ...
) for the synthesis of
cephalosporin antibiotics and intermediates. It can be obtained by
chemoenzymatic hydrolysis
Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution, elimination, and solvation reactions in which water is the nucleophile.
Biological hydrolys ...
of
cephalosporin C
Cephalosporin C is an antibiotic of the cephalosporin class. It was isolated from a fungus of the genus ''Acremonium'' and first characterized in 1961. Although not a very active antibiotic itself, synthetic analogs of cephalosporin C, such as ce ...
.
See also
*
6-APA
6-APA ((+)-6-aminopenicillanic acid) is a chemical compound used as an intermediate in the synthesis of β-lactam antibiotics. The major commercial source of 6-APA is still natural penicillin G: the semi-synthetic penicillins derived from 6-APA a ...
References
{{Organic-compound-stub
Cephalosporin antibiotics
Acetate esters
Sulfur heterocycles