6-Fluoro-DET (6F-DET, 6-fluoro-''N,N''-diethyltryptamine) is a

substituted tryptamine Substituted tryptamines, or serotonin analogues, are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring, joined to an amino group, amino (NH2) group ...

derivative related to drugs such as DET and

5-fluoro-DET 5-Fluoro-DET (5F-DET, 5-fluoro-''N,N''-diethyltryptamine) is a tryptamine derivative related to drugs such as DET and 5-MeO-DET. It acts as an inhibitor of the enzyme myeloperoxidase, and is also thought to be an agonist An agonist is a chem ...

. It acts as a

partial agonist In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonistic e ...

at the 5-HT_2A receptor, but while it produces similar physiological effects to

psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of ...

drugs, it does not appear to produce psychedelic effects itself even at high doses. For this reason it saw some use as an

active placebo An active placebo is a placebo that produces noticeable side effects that may convince the person being treated that they are receiving a legitimate treatment, rather than an ineffective placebo. Nomenclature According to a 1965 paper, the term "c ...

in early

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...

s of psychedelic drugs but was regarded as having little use otherwise, though more recent research into compounds such as

AL-34662 AL-34662 is an indazole derivative drug that is being developed for the treatment of glaucoma. It acts as a selective 5-HT2A receptor agonist, the same target as that of psychedelic drugs like psilocin, but unlike these drugs, AL-34662 was desi ...

and

AAZ-A-154 AAZ-A-154 is a novel isotryptamine derivative which acts as a 5-HT2A receptor, 5-HT2A receptor agonist discovered and synthesized by the lab of Professor David E. Olson at University of California, Davis, UCDavis. Animal studies suggest that it ...

has shown that these kind of non-psychedelic 5-HT_2A agonists can have various useful applications.

References

Psychedelic tryptamines Tryptamines Fluoroarenes {{nervous-system-drug-stub

See also

References