5-HT
5B receptor is a
5-HT receptor
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neur ...
protein and the gene which encodes it. The protein is found in
rodents, but not in
humans, because
stop codons in the gene's coding sequence prevent the gene from expressing a functional protein. It is believed that the function of the 5-HT
5B receptor has been replaced in humans by some other subclass of 5-HT receptor. 5-HT
5B receptor is a
G protein-coupled receptor. 5-HT
5B receptor
mRNA is expressed primarily in the
habenula,
hippocampus and
inferior olive of rat brains.
Known agonists for 5-HT
5B include
ergotamine and
LSD. Known antagonists include
methiothepin
Metitepine (; developmental code names Ro 8-6837 (maleate), VUFB-6276 (mesylate)), also known as methiothepin, is a drug described as a " psychotropic agent" of the tricyclic group which was never marketed. It acts as a non-selective antagonis ...
.
References
Serotonin receptors
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