4F-MDMB-BICA
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4F-MDMB-BINACA (also known as 4F-MDMB-BUTINACA or 4F-ADB) is an
indazole Indazole, also called isoindazole, is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and pyrazole. Indazole is an amphoteric molecule which can be protonated to an indazolium cation or deproton ...
-based synthetic
cannabinoid Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tet ...
from the indazole-3-carboxamide family. It has been used as an active ingredient in synthetic cannabis products and sold as a
designer drug A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. D ...
since late 2018. 4F-MDMB-BINACA is an agonist of the
CB1 receptor Cannabinoid receptor type 1 (CB1), also known as cannabinoid receptor 1, is a G protein-coupled cannabinoid receptor that in humans is encoded by the ''CNR1'' gene. The human CB1 receptor is expressed in the peripheral nervous system and centr ...
(EC50 = 7.39 nM), though it is unclear whether it is selective for this target. In December 2019, the
UNODC The United Nations Office on Drugs and Crime (UNODC; French: ''Office des Nations unies contre la drogue et le crime'') is a United Nations office that was established in 1997 as the Office for Drug Control and Crime Prevention by combining the ...
announced scheduling recommendations placing 4F-MDMB-BINACA into Schedule II throughout the world.


Related compounds

The corresponding indole core analogue, 4F-MDMB-BICA or 4F-MDMB-BUTICA has also been widely sold as a designer drug by chemical providers on the net, first being identified in May 2020.Analytical data for 4F-MDMB-BICA. Hungarian Institute for Forensic Sciences. 28-05-2020
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Legal Status


United Kingdom

It's illegal to sell, distribute, supply, transport or trade the pharmaceutical drug under the
Psychoactive Substances Act 2016 The Psychoactive Substances Act 2016 (c. 2) is an Act of the Parliament of the United Kingdom intended to restrict the production, sale and supply of a new class of psychoactive substances often referred to as "legal highs". The bill was given R ...
.


See also

* 5F-MDMB-PINACA * 5F-MDMB-PICA * 5F-MMB-PINACA * 5F-MPP-PICA *
AB-FUBINACA AB-FUBINACA is a drug that acts as a potent agonist for the cannabinoid receptors, with ''K''i values of 0.9 nM at CB1 and 23.2 nM at CB2 and EC50 values of 1.8 nM at CB1 and 3.2 nM at CB2. It was originally developed by P ...


References

Cannabinoids Designer drugs Organofluorides Indazolecarboxamides Tert-butyl compounds {{cannabinoid-stub