The 412 BC epidemic of an unknown disease, often identified as

influenza Influenza, commonly known as "the flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms ...

, was reported in Northern Greece by

Hippocrates Hippocrates of Kos (; grc-gre, Ἱπποκράτης ὁ Κῷος, Hippokrátēs ho Kôios; ), also known as Hippocrates II, was a Greek physician of the classical period who is considered one of the most outstanding figures in the history of ...

, ''Of the Epidemics'', Boo
I
/ref> and in Rome by

Livy Titus Livius (; 59 BC – AD 17), known in English as Livy ( ), was a Ancient Rome, Roman historian. He wrote a monumental history of Rome and the Roman people, titled , covering the period from the earliest legends of Rome before the traditiona ...

. Both described the

epidemic An epidemic (from Ancient Greek, Greek ἐπί ''epi'' "upon or above" and δῆμος ''demos'' "people") is the rapid spread of disease to a large number of patients among a given population within an area in a short period of time. Epidemics ...

continuing for roughly a year. The disease outbreak caused a food shortage in the

Roman Republic The Roman Republic ( la, Res publica Romana ) was a form of government of Rome and the era of the classical Roman civilization when it was run through public representation of the Roman people. Beginning with the overthrow of the Roman Kin ...

, and a

famine A famine is a widespread scarcity of food, caused by several factors including war, natural disasters, crop failure, Demographic trap, population imbalance, widespread poverty, an Financial crisis, economic catastrophe or government policies. Th ...

was only prevented with food relief from

Sicily (man) it, Siciliana (woman) , population_note = , population_blank1_title = , population_blank1 = , demographics_type1 = Ethnicity , demographics1_footnotes = , demographi ...

and

Etruria Etruria () was a region of Central Italy, located in an area that covered part of what are now most of Tuscany, northern Lazio, and northern and western Umbria. Etruscan Etruria The ancient people of Etruria are identified as Etruscan civiliza ...

, and via

trade mission Trade mission is an international trip by government officials and businesspeople that is organized by agencies of national or provincial governments for purpose of exploring international business opportunities. Business people who attend trade m ...

s to the "peoples round about who dwelt on the Tuscan sea or by the

Tiber The Tiber ( ; it, Tevere ; la, Tiberis) is the third-longest river in Italy and the longest in Central Italy, rising in the Apennine Mountains in Emilia-Romagna and flowing through Tuscany, Umbria, and Lazio, where it is joined by the Riv ...

."Livy, ''The History of Rome'', Boo
IV, 52, 5-6
/ref>

Symptoms

Hippocrates named a wide variety of symptoms, among them: fever, coughing, pain in head and neck, and emaciation. The disease proved fatal most often among prepubescent children.

References

412 BC Ancient health disasters Epidemics History of ancient medicine Influenza outbreaks 5th century BC in the Roman Republic 5th century BC in Greece {{Rome-stub