4-hydroxytestosterone
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4-Hydroxytestosterone (4-OHT), also known as 4,17β-dihydroxyandrost-4-en-3-one, is a synthetic
anabolic-androgenic steroid Anabolic steroids, also known more properly as anabolic–androgenic steroids (AAS), are steroidal androgens that include natural androgens like testosterone as well as synthetic androgens that are structurally related and have similar effects t ...
(AAS) and a
derivative In mathematics, the derivative of a function of a real variable measures the sensitivity to change of the function value (output value) with respect to a change in its argument (input value). Derivatives are a fundamental tool of calculus. F ...
of
testosterone Testosterone is the primary sex hormone and anabolic steroid in males. In humans, testosterone plays a key role in the development of Male reproductive system, male reproductive tissues such as testes and prostate, as well as promoting secondar ...
that was never marketed. It was first patented by G.D. Searle & Company in 1955 and is
testosterone Testosterone is the primary sex hormone and anabolic steroid in males. In humans, testosterone plays a key role in the development of Male reproductive system, male reproductive tissues such as testes and prostate, as well as promoting secondar ...
with a hydroxy group at the four position. 4-OHT has moderate
anabolic Anabolism () is the set of metabolic pathways that construct molecules from smaller units. These reactions require energy, known also as an endergonic process. Anabolism is the building-up aspect of metabolism, whereas catabolism is the breaking-do ...
, mild
androgenic An androgen (from Greek ''andr-'', the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This incl ...
, and anti-aromatase properties and is similar to the steroid
clostebol Clostebol (; also known as 4-chlorotestosterone) usually as the ester clostebol acetate, is a synthetic anabolic–androgenic steroid (AAS). Clostebol is the 4- chloro derivative of the natural hormone testosterone. The chlorination prevents c ...
(4-chlorotestosterone).


See also

* 4-Androstene-3,6,17-trione *
Androstenedione Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of estrone and of testosterone from dehydroepia ...
* Enestebol *
Formestane Formestane, formerly sold under the brand name Lentaron among others, is a steroidal, selective aromatase inhibitor which is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. The drug is not active orally ...
*
11β-Hydroxytestosterone 11β-Hydroxytestosterone is an endogenous steroid, a metabolite of testosterone. See also * Testosterone * Steroid 11β-hydroxylase * 4-Hydroxytestosterone * 11-Ketotestosterone References

{{Endogenous steroids Androstanes ...


References

Androgens and anabolic steroids Androstanes Aromatase inhibitors Exercise physiology Drugs in sport World Anti-Doping Agency prohibited substances {{Genito-urinary-drug-stub