4-Fluoro--threonine is an antibacterial produced by ''

Streptomyces cattleya ''Streptomyces cattleya'' is a Gram-positive bacterium which makes cephamycin, penicillin and thienamycin. The bacterium expresses a fluorinase enzyme, and the organism has been used to understand the biosynthesis of fluoroacetate and the antibac ...

''. It is formed by the

fluorothreonine transaldolase In enzymology, a fluorothreonine transaldolase () is an enzyme that catalyzes the chemical reaction :L-threonine + fluoroacetaldehyde \rightleftharpoons acetaldehyde + 4-fluoro-L-threonine Thus, the two substrates of this enzyme are L-threonin ...

catalysed transfer of

fluoroacetaldehyde Fluoroacetaldehyde is a metabolic precursor of both fluoroacetate and 4-fluorothreonine in ''Streptomyces cattleya ''Streptomyces cattleya'' is a Gram-positive bacterium which makes cephamycin, penicillin and thienamycin. The bacterium express ...

onto

threonine Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH form under biological conditions), a carboxyl group (which is in the deprotonated −COO� ...

References

Fluorinated amino acids Fluorohydrins Fluorine-containing natural products {{organic-compound-stub