In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, a 4-chlorobenzoate—CoA ligase () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:4-chlorobenzoate + CoA + ATP
4-chlorobenzoyl-CoA + AMP + diphosphate
The 3
substrates of this enzyme are
4-chlorobenzoate,
CoA
Coa may refer to:
Places
* Coa, County Fermanagh, a rural community in County Fermanagh, Northern Ireland
* Côa River, a tributary of the Douro, Portugal
** Battle of Coa, part of the Peninsular War period of the Napoleonic Wars
** Côa Vall ...
, and
ATP
ATP may refer to:
Companies and organizations
* Association of Tennis Professionals, men's professional tennis governing body
* American Technical Publishers, employee-owned publishing company
* ', a Danish pension
* Armenia Tree Project, non ...
, whereas its 3
products are
4-chlorobenzoyl-CoA,
AMP, and
diphosphate.
This enzyme belongs to the family of
ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The
systematic name of this enzyme class is 4-chlorobenzoate:CoA ligase. This enzyme participates in
2,4-dichlorobenzoate degradation. It employs one
cofactor,
magnesium.
Structural studies
As of late 2007, two
structures have been solved for this class of enzymes, with
PDB accession codes and .
References
*
*
*
EC 6.2.1
Magnesium enzymes
Enzymes of known structure
{{ligase-stub