4-Piperidinone is a derivative of
piperidine with the
molecular formula C5 H9 N O. 4-Piperidone is used as an intermediate in the manufacture of chemicals and
pharmaceutical drug
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and re ...
s.
Piperidones
Piperidones are a class of chemical compounds sharing the piperidone skeleton. A classic named reaction for the synthesis of piperidones is the
Petrenko-Kritschenko piperidone synthesis
The Petrenko-Kritschenko reaction is a classic multicomponent-name reactionJie-Jack Li; "Name reactions in heterocyclic chemistry"; 2005 John Wiley & Sons; ; pp313 that is closely related to the Robinson–Schöpf tropinone synthesis, but was publ ...
which involves combining an alkyl-1,3-acetonedicarboxylate with
benzaldehyde
Benzaldehyde (C6H5CHO) is an organic compound consisting of a benzene ring with a formyl substituent. It is the simplest aromatic aldehyde and one of the most industrially useful.
It is a colorless liquid with a characteristic almond-like odor. ...
and an
amine
In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen atoms have been replaced by a substituen ...
.
This multicomponent reaction is related to the
Hantzsch pyridine synthesis
The Hantzsch pyridine synthesis or Hantzsch dihydropyridine synthesis is a multi-component organic reaction between an aldehyde such as formaldehyde, 2 equivalents of a β-keto ester such as ethyl acetoacetate and a nitrogen donor such as ammoni ...
.
See also
*
4-Pyridone
4-Pyridone is an organic compound with the formula . It is a colorless solid. The compound exists in equilibrium with a minor tautomer, pyridin-4-ol.
Preparation
4-Pyridone, and its Derivative (chemistry), derivatives, are prepared from 4-Pyron ...
References
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