4-Nitrobenzoic acid is an
organic compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. T ...
with the
formula C
6H
4(NO
2)CO
2H. It is a pale yellow solid. It is a precursor to 4-nitrobenzoyl chloride, the precursor to the anesthetic
procaine
Procaine is a local anesthetic drug of the amino ester group. It is most commonly used in dental procedures to numb the area around a tooth and is also used to reduce the pain of intramuscular injection of penicillin. Owing to the ubiquity ...
and
folic acid
Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as a dietary supplement and in food fortification as it is more stable during processing and ...
. It is also a precursor to
4-aminobenzoic acid
4-Aminobenzoic acid (also known as ''para''-aminobenzoic acid or PABA because the two functional groups are attached to the benzene ring across from one another in the ''para'' position) is an organic compound with the formula H2NC6H4CO2H. PABA i ...
.
Production
4-Nitrobenzoic acid is prepared by oxidation of
4-nitrotoluene
4-Nitrotoluene or ''para''-nitrotoluene is an organic compound with the formula CH3C6H4NO2. It is a pale yellow solid. It is one of three isomers of nitrotoluene.
Synthesis and reactions
Together with other isomers, 4-nitrotoluene is prepared by ...
using oxygen or dichromate as oxidants.
:
Alternatively, it has been prepared by nitration of
polystyrene followed by oxidation of the alkyl substituent. This method proceeds with improved para/ortho selectivity owing to the steric protection of the ortho positions by the polymer backbone.
Safety
This compound has a rat of 1960 mg/kg.
References
{{DEFAULTSORT:Nitrobenzoic acid, 4-
Benzoic acids
Nitrobenzenes