4-DAMP (1,1-dimethyl-4-diphenylacetoxypiperidinium iodide) is a selective
muscarinic acetylcholine receptor
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells. They play several roles, including acting as the main end-rece ...
(mAChR) M
3 antagonist
An antagonist is a character in a story who is presented as the chief foe of the protagonist.
Etymology
The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, riv ...
. It is also able to antagonize M
1 receptors but "prefers" M
3.
It competitively binds to the acetylcholine binding site on mAChRs, causing right-ward shift in the dose response curves for mAChR agonists.
References
Muscarinic antagonists
Iodides
Carboxylate esters
Piperidines
Quaternary ammonium compounds
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