4-Acetoxy-DET (4-Acetoxy-''N'',''N''-diethyltryptamine), also known as ethacetin, ethylacybin or 4-AcO-DET, is a
psychedelic tryptamine
Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole ─ a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the f ...
. It was first synthesized in 1958 by
Albert Hofmann
Albert Hofmann (11 January 1906 – 29 April 2008) was a Swiss chemist known for being the first to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD). Hofmann's team also isolated, named and synthesi ...
in the
Sandoz
Novartis AG is a Swiss-American multinational pharmaceutical corporation based in Basel, Switzerland and
Cambridge, Massachusetts, United States (global research).name="novartis.com">https://www.novartis.com/research-development/research-loca ...
lab.
[Erowid 4-Acetoxy-DET Vaults : Primer](_blank)
Accessed on April 19, 2007.
It is expected that the compound is quickly
hydrolyzed into the free phenolic
4-HO-DET
4-HO-DET, also known as 4-hydroxy-diethyl-tryptamine, CZ-74, is a hallucinogenic drug and psychedelic compound of moderate duration. 4-HO-DET is a substituted tryptamine, structurally related to psilocin, ethocybin, and 4-HO-DIPT.
Analogs
The a ...
by
serum esterase
The enzyme cholinesterase (EC 3.1.1.8, choline esterase; systematic name acylcholine acylhydrolase) catalyses the hydrolysis of choline-based esters:
: an acylcholine + H2O = choline + a carboxylate
Several of these serve as neurotransmitter ...
s, but human studies concerning the metabolic fate of this drug are lacking.
Dosage
4-Acetoxy-DET is orally active, and dosages of 10–25 mg are common. Effects last 4–6 hours.
The free
base is also active when smoked in a dose range of 5–20 mg.
Smoking 4-acetoxy-DET greatly speeds up the onset;
peak Peak or The Peak may refer to:
Basic meanings Geology
* Mountain peak
** Pyramidal peak, a mountaintop that has been sculpted by erosion to form a point Mathematics
* Peak hour or rush hour, in traffic congestion
* Peak (geometry), an (''n''-3)-di ...
effects are experienced within 10 minutes, and are usually over within 1 hour.
Drug prohibition laws
Sweden
''Sveriges riksdags'' health ministry
''Statens folkhälsoinstitut'' classified 4-AcO-DET as "health hazard" under the act
''Lagen om förbud mot vissa hälsofarliga varor'' (translated ''Act on the Prohibition of Certain Goods Dangerous to Health'') as of Nov 1, 2005, in their regulation SFS 2005:733 listed as 4-acetoxi-N,N-dietyltryptamin (4-AcO-DET), making it illegal to sell or possess.
References
External links
Erowid 4-Acetoxy-DET vaultClassification document by the Swedish Institute of Health regarding 4-Acetoxy-DET
{{DEFAULTSORT:Acetoxy-Det, 4-
Acetate esters
Psychedelic tryptamines
Designer drugs
Diethylamino compounds
Substances discovered in the 1950s