3β-Methoxypregnenolone (developmental code name MAP-4343), or pregnenolone 3β-methyl ether, also known as 3β-methoxypregn-5-en-20-one, is a
synthetic neuroactive steroid and
derivative
In mathematics, the derivative of a function of a real variable measures the sensitivity to change of the function value (output value) with respect to a change in its argument (input value). Derivatives are a fundamental tool of calculus. ...
of
pregnenolone
Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/ metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineraloc ...
.
It interacts with
microtubule-associated protein 2
Microtubule-associated protein 2 is a protein in humans that is encoded by the ''MAP2'' gene.
Function
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family were originally isolated s ...
(MAP2) in a similar manner to pregnenolone and is under development for potential clinical use for indications such as the treatment of
brain
A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a ve ...
and
spinal cord injury
A spinal cord injury (SCI) is damage to the spinal cord that causes temporary or permanent changes in its function. Symptoms may include loss of muscle function, sensation, or autonomic function in the parts of the body served by the spinal cor ...
and
depressive disorder
A mood disorder, also known as an affective disorder, is any of a group of conditions of mental and behavioral disorder where a disturbance in the person's mood is the main underlying feature. The classification is in the ''Diagnostic and Stat ...
s.
See also
*
List of investigational antidepressants
This is a list of investigational antidepressants, or antidepressants that are currently under development for clinical use in the treatment of mood disorders but are not yet approved. ''Chemical/generic names are listed first, with developmental ...
*
List of neurosteroids
This is a list of neurosteroids, or natural product, natural and synthetic compound, synthetic steroids that are active on the mammalian nervous system through receptor (biochemistry), receptors other than steroid hormone receptors. It includes ...
References
Experimental antidepressants
Neuroprotective agents
Neurosteroids
Pregnanes
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