3-Methylcrotonyl-CoA or β-Methylcrotonyl-CoA is an intermediate in the metabolism of leucine. It is found in mitochondria, where it is formed from

isovaleryl-coenzyme A Isovaleryl-coenzyme A, also known as isovaleryl-CoA, is an intermediate in the metabolism of branched-chain amino acids. Leucine metabolism See also * Isovaleryl coenzyme A dehydrogenase In enzymology, an isovaleryl-CoA dehydrogenase () is an ...

isovaleryl coenzyme A dehydrogenase In enzymology, an isovaleryl-CoA dehydrogenase () is an enzyme that catalyzes the chemical reaction :3-methylbutanoyl-CoA + acceptor \rightleftharpoons 3-methylbut-2-enoyl-CoA + reduced acceptor Thus, the two substrates of this enzyme are 3-met ...

. It then reacts with CO₂ to yield

3-Methylcrotonyl-CoA carboxylase Methylcrotonyl CoA carboxylase (, MCC) (3-methylcrotonyl CoA carboxylase, methylcrotonoyl-CoA carboxylase) is a biotin-requiring enzyme located in the mitochondria. MCC uses bicarbonate as a carboxyl group source to catalyze the carboxylation ...

Leucine metabolism

References

Thioesters of coenzyme A {{biochem-stub