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3-hexulose-6-phosphate synthase (, ''D-arabino-3-hexulose 6-phosphate formaldehyde-lyase'', ''3-hexulosephosphate synthase'', ''3-hexulose phosphate synthase'', ''HPS'') is an
enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ...
''D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming)''. This enzyme catalyses the following
chemical reaction A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
: D-arabino-hex-3-ulose 6-phosphate \rightleftharpoons D-ribulose 5-phosphate +
formaldehyde Formaldehyde ( , ) (systematic name methanal) is a naturally occurring organic compound with the formula and structure . The pure compound is a pungent, colourless gas that polymerises spontaneously into paraformaldehyde (refer to section F ...
This enzyme requires Mg2+ or Mn2+ for maximal activity.


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* {{Portal bar, Biology, border=no EC 4.1.2