3-Methylcrotonyl-CoA or β-Methylcrotonyl-CoA is an
intermediate in the metabolism of
leucine.
It is found in mitochondria, where it is formed from
isovaleryl-coenzyme A
Isovaleryl-coenzyme A, also known as isovaleryl-CoA, is an intermediate in the metabolism of branched-chain amino acids.
Leucine metabolism
See also
* Isovaleryl coenzyme A dehydrogenase
In enzymology, an isovaleryl-CoA dehydrogenase () is an ...
by
isovaleryl coenzyme A dehydrogenase
In enzymology, an isovaleryl-CoA dehydrogenase () is an enzyme that catalyzes the chemical reaction
:3-methylbutanoyl-CoA + acceptor \rightleftharpoons 3-methylbut-2-enoyl-CoA + reduced acceptor
Thus, the two substrates of this enzyme are 3-met ...
. It then reacts with CO
2 to yield
3-Methylcrotonyl-CoA carboxylase
Methylcrotonyl CoA carboxylase (, MCC) (3-methylcrotonyl CoA carboxylase, methylcrotonoyl-CoA carboxylase) is a biotin-requiring enzyme located in the mitochondria. MCC uses bicarbonate as a carboxyl group source to catalyze the carboxylation ...
.
Leucine metabolism
See also
*
Methylcrotonyl-CoA carboxylase
References
Thioesters of coenzyme A
{{biochem-stub