3-Maleylpyruvic acid, or 3-maleylpyruvate, is a dicarboxylic acid formed by the oxidative ring opening of
gentisic acid
Gentisic acid is a dihydroxybenzoic acid. It is a derivative of benzoic acid and a minor (1%) product of the metabolic break down of aspirin, excreted by the kidneys.
It is also found in the African tree ''Alchornea cordifolia'' and in wine.
Pro ...
by
gentisate 1,2-dioxygenase
In enzymology, a gentisate 1,2-dioxygenase () is an enzyme that catalyzes the chemical reaction
:2,5-dihydroxybenzoate + O2 \rightleftharpoons maleylpyruvate
Thus, the two substrates of this enzyme are 2,5-dihydroxybenzoate and O2, whereas its ...
during the metabolism of tyrosine. It is converted into
3-fumarylpyruvate
3-Fumarylpyruvic acid, or 3-fumarylpyruvate, is a dicarboxylic acid formed from the isomerisation of 3-maleylpyruvate by maleylpyruvate isomerase. It is converted into fumarate and pyruvate
Pyruvic acid (CH3COCOOH) is the simplest of the alp ...
by
maleylpyruvate isomerase
In enzymology, a maleylpyruvate isomerase () is an enzyme that catalyzes the chemical reaction
:3-maleylpyruvate \rightleftharpoons 3-fumarylpyruvate
Hence, this enzyme has one substrate, 3-maleylpyruvate, and one product, 3-fumarylpyruvate.
...
.
References
Dicarboxylic acids
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