The Putative 3 TMS Holin (3-Hol) Family
TC# 1.E.56 is large, consisting of many members derived from
Pseudomonadota
Pseudomonadota (synonym Proteobacteria) is a major phylum of Gram-negative bacteria. The renaming of phyla in 2021 remains controversial among microbiologists, many of whom continue to use the earlier names of long standing in the literature. The ...
and their
phage, all of small size (85-105 amino acyl residues in length) and usually with 3 transmembrane segments (TMSs). A representative list of the proteins belonging to this family can be found in th
Transporter Classification Database While many of the proteins belonging to this family are annotated in holins, they remain functionally uncharacterized.
See also
*
Holin
*
Lysin
Lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic cycle. Lysins are highly evolved enzymes that are able to target ...
*
Transporter Classification Database
Further reading
* Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01)
"Topological and phylogenetic analyses of bacterial holin families and superfamilies" ''Biochimica et Biophysica Acta (BBA) - Biomembranes'' 1828 (11): 2654–2671. . . .
* Saier, Milton H.; Reddy, Bhaskara L. (2015-01-01)
"Holins in Bacteria, Eukaryotes, and Archaea: Multifunctional Xenologues with Potential Biotechnological and Biomedical Applications" ''Journal of Bacteriology'' 197(1): 7–17. . . . .
* Wang, I. N.; Smith, D. L.; Young, R. (2000-01-01)
"Holins: the protein clocks of bacteriophage infections" ''Annual Review of Microbiology'' 54: 799–825. . . .
References
{{CCBYSASource, sourcepath=http://tcdb.org/search/result.php?tc=1.E.56, sourcearticle=1.E.56. The Putative 3 TMS Holin (3-Hol) Family, revision=699838558
Holins